Study in PNAS remains high in Online Impact after more than 7 months after publication

Study in PNAS remains high in Online Impact after more than 7 months after publication

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Our study still remains high in its online altimetric scores many months after its publication. According to the PNAS website, our article lies in the top 5% of all articles ranked by attention. It is reported to make very good compared to articles of the same age (99th percentile). So far Altmetric has tracked 24,829 articles from this journal. They typically receive a lot more attention than average, with a mean score of 15.7 vs the global average of 5.1. Our PNAS Kawasaki article has done particularly well, scoring higher than 99% of its peers. More generally, Altimetric has tracked 2,793,987 articles across all journals so far. Compared to these this article has done particularly well and is in the 99th percentile: it’s in the top 5% of all articles ever tracked by Altimetric.

We see that our study has caught a lot of attention. More to come, stay tuned!

imatge notícia 6See more details

Article PNAS-USA Number #14-00380: “Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan,” by Xavier Rodó et al.

New aircraft campaign scheduled in Japan in February 2015… if funds arrive

New aircraft campaign scheduled in Japan in February 2015… if funds arrive

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A new focused aircraft monitoring campaign is scheduled to take place over NW Japan next February, if IC3 scientists manage to gather the amount of funds needed to cover for the costs of the flights. The objective is to further test whether the Candida hypothesis or the environmental toxin agent, both raised in the latest published results is the relevant potential trigger for Kawasaki disease. The researchers now plan to conduct more flights over NW Japan during the high season for Kawasaki disease, exactly over the research station where new equipment was deployed last summer and where a continuous surface air sampling is taking place at the moment. This way, scientists plan to relate what happens atop with surface samples and eventually with the admission of new patients in nearby Toyama and Kanazawa hospitals (see other pieces in Latest News).

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To further proceed, IC3 launched a fund-raising initiative to gather funds to perform these aircraft monitoring campaigns this year and the next. These samples would enable us to continue our research towards an accurate characterization of the nature of this environmental trigger (see DONATE at this same website, www.kawasaki-disease.com ).

KD doctors at Toyama and Kanazawa Medical hospitals join the Kawasaki Consortium

KD doctors at Toyama and Kanazawa Medical hospitals join the Kawasaki Consortium

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IC3 and the Kawasaki Disease consortium have established a new joint collaboration with scientists at both Toyama and Kanazawa Hospitals to advance research onto causes of Kawasaki disease. Medical doctor experts on cardiomyopathies and Kawasaki disease Dr. Fukiko Ichida from the University of Toyama and Dr. Tsuneyuki Nakamura in Kanazawa Medical School have recently added to our research consortium. They will provide data of admitted Kawasaki disease patients in a network of branch hospitals at their prefectures.

foto Notícia 8

Semi-real-time reporting of KD cases in Toyama and Kanazawa with date of onset of fever will serve to trace what is the evolution of hospital KD admissions concomittant with the atmospheric sampling taking place at Ishikawa. Continuous air sampling equipments were deployed in a research station on the coast near both major cities at Ishikawa (see other news). The ultimate aim of this initiative is to be able to compare the contents of the aerosol samples with fluctuations in KD activity in the region. By using location of primary residence of anonymous sick children data, scientists plan to perform a fine backtracing of the air masses thanks to the use of high-resolution atmospheric simulations with FLEXPART-WRF computer models.

Same study demonstrates the Kawasaki disease agent does not act as an infectious disease

Same study demonstrates the Kawasaki disease agent does not act as an infectious disease

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A long time has passed since the first Kawasaki disease patient was identified in Japan by Dr. Tomisaku Kawasaki and yet no agreement on its cause and potential agent/s has consistently emerged. Different theories suggested different epidemiological pathways, ranging from a typical infectious disease to different kinds of exacerbated host responses in susceptible children being exposed to one or more noninfectious environmental triggers. Some consensus existed, however, that whatever the trigger was, it enters through the mucosa of the upper respiratory tract. Therefore, assuming that the KD agent is carried by the wind, cases should occur simultaneously in neighboring towns due to the large scale reach of wind patterns and/or propagate fast through infection. The study effectively showed how in cities belonging to the greater Tokyo area on average separated around 30Km, peak incidences of Kawasaki disease occurred simultaneously, that is the same day or one day apart. The epidemiological study showed maximum coherence in the daily variability of Kawasaki patients in cities like Tokyo, Yokohama, Saitama and Chiba. Applying a mathematical model for infectious diseases further confirmed that not even the fastest infectious agent could display on the basis of secondary cases, such a rapid propagation as the one seen for this disease. Therefore, our study discards the action of an infectious agent having to replicate in the host coursing as an infection, and instead favors as the most likely trigger, the role of an idiosyncratic immune response to an environmental particle or toxin.

imatge Notícia 2

Article PNAS-USA Number #14-00380: “Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan,” by Xavier Rodó et al..(http://www.pnas.org/content/111/22/7952.full.pdf+html).